Pharmacokinetics and Tissue Distribution of Anidulafungin in Rats
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منابع مشابه
Pharmacokinetics and tissue distribution of anidulafungin in rats.
This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.
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Running Title: Anidulafungin for Candida Endophthalmitis 7 Livermore, J.L.,Felton, T.W.,Abbott, J., Sharp, A., Goodwin, J.,Gregson, L., Warn, 8 P.A.,Howard, S.J.,Hope W.W* 9 The University of Manchester, Manchester Academic Health Science Centre, NIHR 10 Translational Research Facility in Respiratory Medicine, University Hospital of South 11 Manchester NHS Foundation Trust, Manchester, UK 12 2 ...
متن کاملDoes Weight Impact Anidulafungin Pharmacokinetics?
Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01596-07